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GCLC also exerts a non-canonical, GSH-independent protective function by maintaining glutamate homeostasis during cystine starvation 145

Autoimmune encephalitis (where symptoms include psychiatric features, confusion, memory loss and seizures followed by a movement disorder, loss of consciousness and autonomic fluctuations) and related disorders have also been associated with anti GABA-B receptor antibodies and/or glutamic acid decarboxylase (GAD the enzyme responsible for converting glutamic acid to GABA) antibodies (Boronat et al, 2011)

59 Importantly, GSH mediates regulatory S-glutathionylation of proteins

(2011): Found that glutathione deficiency is common in aging and metabolic syndrome, and supplementation with NAC can restore redox balance